Serial Changes in Cardiac Strain and Contractility After Hematopoietic Stem Cell Transplantation in Patients with Hematologic Malignancies

Hematopoietic stem cell transplantation (HSCT) is occasionally associated with cardiac dysfunction during long-term follow-up. Global longitudinal strain (GLS) has emerged as an early predictor of cardiotoxicity cancer therapy; however, the serial changes in GLS before and after HSCT have not been elucidated. To clarify association between GLS, we investigated HSCT. We evaluated function 1, 3, 6 months 38 consecutive patients enrolled this study. Overall, left ventricular (LV) ejection fraction (EF) temporally decreased 1 month post-HSCT. LVEF completely recovered to baseline at 3 HSCT, whereas partially Except for five who died within months, values low EF group (LVEF ? 55% post-HSCT, n = 6) were significantly consistently lower than those normal > 27) any time These findings suggest that might be a decrease hematologic malignancies. Further prospective data will important understanding management HSCT-associated dysfunction.